The many roles of the transcriptional regulator CTCF
- 1 June 2003
- journal article
- review article
- Published by Canadian Science Publishing in Biochemistry and Cell Biology
- Vol. 81 (3) , 161-167
- https://doi.org/10.1139/o03-052
Abstract
The nuclear factor CTCF was first identified as one of the factors binding to the regulatory regions of the c-myc gene. Further study of this protein revealed roles in transcriptional repression, insulator function, and imprinting genetic information. Recent studies have provided new insight into the mechanism through which this factor acts at various levels of gene regulation.Keywords
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