Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis

Publisher Website
Google Scholar
Abstract
The topical effects of No164 [sodium p-benzyl-4-[1-oxo-2-(4-chlorobenzyl)-3-phenylpropyl]phenyl phosphonate] (a phenyl phosphonate derivative which is a partially selective antagonist of prostaglandin E2), indomethacin and triamcinolone acetonide reduced the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema. Oxazolone sensitized Swiss Webster mice were used, ear erythema and ear weights being used as a measure of the anti-inflammatory response to the drugs. No164 was also shown to have systemic anti-inflammatory activity after i.p. injection.