Effect of Epinephrine on Adrenal Ascorbic Acid Following Premedication With Lysergic Acid Diethylamides or 5-Hydroxyindolalkylamines

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Abstract
The adrenal ascorbic acid content of Wistar rats was reduced (P < .05) two hours after intraperltoneal injections of bufotenln (I) 1 mg/kg, serotonin (II) 0.500 mgAg, lysergic acid diethylamide (III) 0.2 mg/kg; 0.4 mg/kg of d-2-bromlysergic acid diethylamide (TV) were ineffective. The intraperltoneal injection of 0.03 mgAg of both (I) and (n) and 0.01 mgAg of (HI) reduced (P <.05) the adrenal ascorbic acid content when injected intraperitoneally with 0.025 mgAg of epinephrine which are per se ineffective; 0.04 mgAg of (IV) do not potentiate epinephrine. The threshold doses of (I) and (II) potentiating epinephrine effects on cats nictitating membrane are respectively 0.0048 mgAg intravenously (S.E. 0.0034-0.0068) and 0.088 mgAg (S.E. .0576-. 1345). (I) and (II) 0.025 to 0.150 mg/kg intravenously failed to potentiate in cats the hypertensive effects of epinephrine. (I) and (II) did not modify the effects of epinephrine on the isolated ileum and spleen of rabbits.

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