Suppression of Mouse Ependymoma Growth after Immunization with Tumor Ribosomal Complexes

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Abstract
Immunization with ribosomal complexes, prepared from experimental ependymomas (transplanted in C57B/6J female mice) significantly decreases tumor growth and prolongs survival of hosts transplanted with this particular tumor. Experimental brain tumors present an interesting model for immunological studies because of the ‘priviledged’ situation of the brain itself, the lack of local lymphatic apparatus and the functional peculiarity of the blood-brain barrier. We studied a tumor model originally induced by methyl-cholanthrene and subsequently transplanted by Zimmerman and Arnold since 1940 [1]. The tumors grow either intracranially or subcutaneously in female mice of the inbred strain C57B/6J; their histopathology is considered stable. The immunogenicity of this tumor to the host has been demonstrated by Wilkins and Ketcham [2].

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