Abstract
To the Editor: A severe febrile reaction occurred in a 38-year-old woman with multiple myeloma after transfusion of 60 ml of packed red cells. The transfusion was stopped immediately. Over the ensuing hour, profound septic shock developed that was complicated by disseminated intravascular coagulation, noncardiogenic pulmonary edema, rhabdomyolysis, and acute renal failure. Antibiotic therapy (tobramycin and ceftazidime) and intensive supportive care were provided; the patient recovered completely. An inspection of the donor blood unit showed no gross abnormalities; however, a Gram's stain showed an abundance of gram-negative rods. Cultures of both the donor blood unit and the patient's blood grew . . .