Neural‐tube defects produced in Syrian hamsters by potato glycoalkaloids

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Abstract
Keeler et al. (78) showed that potato sprouts could be teratogens for the central nervous system in the Syrian hamster. We demonstrate here the same teratogenic effects from a British cultivar, Arran Pilot. Most of the activity was traced to the two solanidine triglycosides, α‐chaconine and, at a higher dose level, α‐solanine. Some possible implications for the study of human neural‐tube defects are considered.