GAUCHER'S DISEASE AND BENIGN MONOCLONAL GAMMAPATHY

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Abstract
A case of chronic non‐neuronopathic Gaucher's disease is presented. The diagnosis was based on the finding of typical Gaucher cells in the bone marrow and spleen. The patient also had a benign monoclonal gammapathy. Immunofluorescence studies of bone marrow and spleen were performed using monospecific antisera against immunoglobulin heavy and light chains. The results indicate a monoclonal plasma cell proliferation in the bone marrow, whereas the distribution of plasma cells in the spleen was polyclonal. The combination of chronic Gaucher's disease and monoclonal gammapathy was also found in the patient's brother.