IMMUNOADJUVANT ACTIVITIES OF SYNTHETIC 6-O-ACYL-N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE WITH SPECIAL REFERENCE TO EFFECT OF ITS ADMINISTRATION WITH LIPOSOMES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 20  (3-4) , 95-103
Abstract
Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy group at the C-6 position of N-acetylmuramyl-L-alanyl-D-isoglutamine [NAMAI, the minimum structure required for the adjuvant activity of bacterial cell walls] gave lipophilic derivatives that had definite adjuvancies in induction of delayed-type hypersensitivity and enhancement of antibody production against a test protein antigen, ovalbumin, when administered to guinea pigs as liposomes, i.e., without mineral oil. When administered as mineral oil-in-water emulsion, including Ribi-type emulsions, rather than as water-in-mineral oil emulsions, NAMAI and its 6-O-acyl derivatives showed only weak immunoadjuvancies.

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