Lipase-Catalyzed Dynamic Kinetic Resolution of Chiral Amines: Use of Palladium as the Racemization Catalyst

Open Access

18 December 1996

journal article
Published by Swiss Chemical Society in Chimia

Vol. 50 (12) , 668
https://doi.org/10.2533/chimia.1996.668

Abstract

The simultaneous use of a biocatalyst (lipase Candida antarctica) and a transition-metal catalyst (palladium) makes the dynamic kinetic resolution of racemic phenylethylamine possible, conversion to the enantiomerically pure N-acylated form being 75–77% (ee = 99%).

Keywords

CHIRAL
DYNAMIC KINETIC
KINETIC RESOLUTION
SIMULTANEOUS
CONVERSION
PHENYLETHYLAMINE
ENANTIOMERICALLY
ACYLATED

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