Baclofen in the Treatment of Detrusor-sphincter Dyssynergia in Spinal Cord Injury Patients

Publisher Website
Google Scholar
Abstract
The pharmacodynamics of baclofen on the bladder and urethral sphincters in male acute and chronic spinal cord injury patients were evaluated. A total of 100 supine and sitting urodynamic profiles was done in 25 patients. Baclofen decreased external urethral sphincter resistance by depressing pudendal-to-pudendal nerve reflex through spinal cord presynaptic hyperpolarization. This new centrally acting antispastic drug produced a significant reduction of residual urine in 73% of the cases within an average of 4.98 wk. Baclofen is a new alternative in the medical treatment of postural nonelectrically induced detrusor striated sphincter dyssynergia in spinal cord injury patients. Indications for external sphincterotomy are discussed.