Protein a from Staphylococcus Aureus
Open Access
- 1 September 1969
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 103 (3) , 467-473
- https://doi.org/10.4049/jimmunol.103.3.467
Abstract
Protein A from Staphylococcus aureus added to guinea pig serum inactivates the hemolytic complement (C′) of the serum. Preformed aggregates of protein A and guinea pig or human IgG inactivate complement. It is probable that the complement-consuming property of protein A is due to its ability to combine with the Fc part of the IgG, thus rendering the IgG complement-fixing. The possibility that the in vivo sensitivity-promoting activity of protein A is due to its ability to activate the complement system is discussed. A hemagglutination technique was developed in order to determine small amounts of protein A.Keywords
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