ACUTE TURPENTINE INFLAMMATION AND KININ RELEASE IN RAT-PAW THERMIC EDEMA

  • 1 January 1981
    • journal article
    • research article
    • Vol. 62  (6) , 591-594
Abstract
Livers from rats at 2-3 days after s.c. injection of turpentine, when perfused, synthesized prekallikrein nearly 3 times faster than did livers from normal rats. Paw edema produced by heating to 46.degree. C, in rats injured in this way was less marked. In such rats the amount of bradykinin release by 50 min of coaxial perfusion of the paw was only 13.6 .+-. 4.6 compared with 63.1 .+-. 13.4 ng in normal rats. A possible explanation for the observed reduction in production of bradykinin may be inhibition of kallikrein due to an increased concentration of .alpha.2-macroglobulin.