A STUDY OF THE PHARMACOLOGICAL PROPERTIES OF THE INSECTICIDE ALDRIN (HEXACHLOROHEXAHYDRODIMETHANONAPHTHALENE)

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Abstract
The effects of Aldrin were studied in acute experiments on cats, dogs, guinea pigs, rabbits, and frogs; in vitro experiments with Aldrin on strips of guinea pig and rabbit intestine and uterus, and on frog sciatic gastrocnemius preparations, were also performed. Aldrin had no effect on isolated tissues, but when injected intravenously, intramuscularly, or intra-arterially it caused bradycardia, vasodepression, and miosis, and potentiated the effect of vagal stimulation on the heart; increased secretory and vasodilator effects of chorda tympani stimulation on the submaxillary salivary gland; and potentiated the effects of acetylcholine. In appropriate quantities it also increased intestinal motility, while in excessive amounts it caused the opposite effect. Both atropine and sodium pentobarbital antagonized some of the effects of Aldrin on the para sympathetic system. Introduced into the lymph sac of frogs and intra-arterially into the spinal cord of spinal or decerebrate cats, Aldrin caused convulsive twitches and in the latter preparation augmented reflex excitability of the spinal cord. It also increased markedly.the excitability of spinal centers to acetylcholine and to metrazol. Aldrin evoked a series of twitches in the denervated striated muscles of the cat, and increased the muscular contractions induced by acetylcholine or by electrical stimulation of the motor nerve. Repeated administration of Aldrin depressed the excitability of the spinal cord and neuromuscular transmission. Although Aldrin is very similar in action to the known anticholinesterases, its toxic effects may be due to some quite different properties.
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