Appearance and localization of dystrophin in normal human fetal muscle
- 1 January 1991
- journal article
- Published by Wiley in International Journal of Developmental Neuroscience
- Vol. 9 (6) , 607-612
- https://doi.org/10.1016/0736-5748(91)90022-e
Abstract
We studied the localization of dystrophin in normal human fetal muscle by immunohistochemistry. Our results show the appearance of dystrophin at week 11 and a progressive organization of the protein along membrane in the following weeks of gestation. At week 22 almost all fibers show a clear membrane immunostaining. Concomitant analysis of muscle fiber-type composition reveals no correlation between progressive appearance of dystrophin and muscle fiber-type differentiation. Our findings suggest that synthesis and localization of dystrophin in developing human skeletal muscle is time-related and probably independent of neuronal influences.Keywords
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