THE ACTION OF DEOXYCORTICOSTERONE ACETATE AND OF DIETARY SODIUM AND POTASSIUM ON SKELETAL MUSCLE ELECTROLYTE IN ADRENALECTOMIZED RATS

Publisher Website
Google Scholar
Abstract
Changes of electrolyte concns. in skeletal muscle from adrenalectomized rats, with and without treatment with DCA, were investigated. Accumulation of muscle K is prevented by DCA, independently of the K intake of the animal. High dietary Na protects against K accumulation only if dietary K is restricted. In all adrenalectomized animals more Na is lost from skeletal muscles than can be accounted for by changes of the vol. and composition of the extracellular fluid space. This effect is not prevented by DCA in amts. sufficient to prevent K accumulation. Loss of skeletal muscle Na and increase of K are due to independent processes, and the evidence suggests that DCA influences the latter rather than the former.