Vascular Reactivity as Influenced by Acetazolamide, Dichlorophenamide and Mercaptomerin.

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Abstract
Comparison of the effects of acetazolamide and mercaptomerin on vascular responses to norepinephrine and isopropylnorepinephrine on dogs indicates that these diuretics decrease vascular responses to the sympathomimetic agents. These results are similar to those reported previously with chlorothiazide. Dichlorophenamide only decreased the vascular response to isopropyl norepinephrine. These results tend to indicate that the changes were due to augmentation of sodium excretion and not specific for any one diuretic evaluated under the conditions described in this study.

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