LXIII.On the hydration and denaturation of proteins

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Abstract
The cyclol theory of protein structure is further developed with special reference to the hydration and denaturation of the globular proteins. The hydration of protein crystals, it is suggested, comprises intra- and intermolecular water, and, in addition, water directly associated with the fabric of the molecule. As an example, the hydration of egg albumin is considered: on the hypothesis of the 288 residue structure for the 35,000 class of proteins put forward by the present writer in 1936, hydration of 27 per cent, is deduced from the molecular weight for egg albumin put forward by Svedberg in 1937, a figure which may be compared with hydration values of 22 and 32·4 per cent, found by Adair and Adair for egg albumin crystals.

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