Malignant Melanoma in Patients Treated for Psoriasis with Methoxsalen (Psoralen) and Ultraviolet A Radiation (PUVA)
- 10 April 1997
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 336 (15) , 1041-1045
- https://doi.org/10.1056/nejm199704103361501
Abstract
Photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is an effective treatment for psoriasis. However, PUVA is mutagenic, increases the risk of squamous-cell skin cancer, and can cause irregular, pigmented skin lesions. We studied the occurrence of melanoma among patients treated with PUVA.Keywords
This publication has 27 references indexed in Scilit:
- The carcinogenic risk of treatments for severe psoriasisCancer, 1994
- Case-Control Study of Malignant Melanoma in Washington StateAmerican Journal of Epidemiology, 1994
- Wavelengths effective in induction of malignant melanoma.Proceedings of the National Academy of Sciences, 1993
- Genital Tumors among Men with Psoriasis Exposed to Psoralens and Ultraviolet A Radiation (PUVA) and Ultraviolet B RadiationNew England Journal of Medicine, 1990
- Etiological Differences Between Subtypes of Cutaneous Malignant Melanoma: Western Canada Melanoma Study2JNCI Journal of the National Cancer Institute, 1987
- PUVA-induced melanocytic atypia: Is it confined to PUVA lentigines?Journal of the American Academy of Dermatology, 1985
- Cutaneous Squamous-Cell Carcinoma in Patients Treated with PUVANew England Journal of Medicine, 1984
- The PUVA Lentigo: An Analysis of Predisposing FactorsJournal of Investigative Dermatology, 1983
- The PUVA-induced pigmented macule: A lentiginous proliferation of large, sometimes cytologically atypical, melanocytesJournal of the American Academy of Dermatology, 1983
- Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet LightNew England Journal of Medicine, 1974