Comparative Study on the Structure of the Light Chains of Human Immunoglobulins1
- 1 November 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 86 (5) , 1523-1535
- https://doi.org/10.1093/oxfordjournals.jbchem.a132670
Abstract
The primary structure of the variable region of the human λtype Bence Jones protein NIG-48 was determined by analysis of the N-terminal sequence of the completely reduced and amino-ethylated protein, as well as of five cyanogen bromide fragments. The variable region of NIG-48 contains 112 amino acid residues. The protein NIG-48, having a unique sequence of the variable region, a low degree of homology (about 50%) with λchains of the five other subgroups and the addition of two residues around 65, may represent a new subgroup, namely VλVLKeywords
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