Characterization of Amyloid of Ageing Obese–Hyperglycaemic Mice and their Lean Littermates

Publisher Website
Google Scholar
Abstract
Amyloid fibrits, isolated from 18‐month‐old obese–hyperglycaemic mice and their lean littermates, were characterized immunologically and chemically. The main amyloid fibril subunit protein was protein AA, which cross‐reacted completely with an antiserum against amyloid from mice with experimentally induced amyloidosis and had an amino acid composition and N‐terminal amino acid sequence identical to that protein. These results indicate that the spontaneously occurring amyloidosis in obese–hyperglycaemic mice and their lean littermates corresponds to human, secondary amyloidosis and may serve as a model for that disease.