In vivo Chemotaxis and Body Compartment Distribution of Indium-111 Labelled Polymorphonuclear Leukocytes in Burned Guinea Pigs

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Abstract
The in vivo chemotactic response of Indium-111 labelled polymorphonuclear leukocytes (PMNL) and their body compartment distribution have been studied in burned (30% TBSA full-thickness burn) and normal guinea pigs. The in vivo chemotactic response to FMLP 10(-5) M and to zymosan-activated serum of the burned PMNL was not significantly different from that of normal PMNL. However, the burned PMNL leave the circulation more rapidly and localize in the burn area and in the liver to a greater extent. No evidence of increased destruction of burned PMNL by the spleen or by the lungs was found.

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