SYNERGISTIC ANTIPROLIFERATIVE ACTIVITY OF LEUKOCYTE INTERFERON IN COMBINATION WITH ALPHA-DIFLUOROMETHYLORNITHINE AGAINST HUMAN-CELLS IN CULTURE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (6) , 2339-2340
Abstract
.alpha.-Difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, was administered in combination with human leukocyte interferon to human lymphoblastoid (Daudi) cells in culture. True synergistic antiproliferative activity was observed at 72 h after continuous exposure. This effect was observed regardless of the ratio of interferon to .alpha.-difluoromethylornithine concentrations. Although the mechanisms by which this effect occurs are unknown, these studies provide a rationale for combination clinical trials of .alpha.-difluoromethylornithine with leukocyte interferon.

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