A case of small cell carcinoma arising in a mature cystic teratoma of the ovary

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Abstract
Malignant transformation of ovarian mature cystic teratomas is reported to occur in about 1% of cases. The most common malignant evolution is that of squamous cell carcinoma and one of the least common is that of small cell carcinoma. We report a case of distant metastasis from a small cell carcinoma arising in a mature cystic teratoma. A 28‐year‐old nulliparous female presented with signs of supraclavicutar lymph node metastasis. This Is the first known case report of lymph node metastasis as an Initial sign of cancer developing in a pre‐existing mature cystic teratoma. Histologically, the tumor cells had microscopic features similar to those of pulmonary small cell carcinoma. This report gives a literature review, and the histological, Immunohistochemical, flow cytometric and ultrastructural features are described.