Binding of cis-dichlorobis(1-methylimidazole-2-thiol)-palladium(II) and -platinum(II) to nucleosides: synthesis and hydrogen-1 and carbon-13 nuclear magnetic resonance studies
- 1 January 1977
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 16,p. 1588-1593
- https://doi.org/10.1039/dt9770001588
Abstract
The reactions of cis-[MCl2(mit)2](M = Pd or Pt; mit = 1-methylimidazole-2-thiol) with guanosine (guo), cytidine (cyd), and adenosine (ado) have been studied in neutral solutions. Two types of complexes have been isolated, of general formula [M(mit)2L2]X2(L = guo or cyd) and [ML4]X2(L = cyd or ado) with X = Cl– and [PF6]–. By use of i.r. spectroscopy and of the chemical shifts occurring in 1H and 13C n.m.r. spectroscopy, it is possible to confirm co-ordination of Pd and Pt to N7 in guo and ado, and to N6 in cyd. The n.m.r. investigations reflect electronic modifications in the ring system of the co-ordinated nucleosides, which are discussed in terms of DNA denaturation by heavy transition-metal complexes.Keywords
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