PERIOSTEAL OSSIFICATION IN MYELOGENOUS LEUKEMIA
- 1 June 1934
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1908)
- Vol. 53 (6) , 938-952
- https://doi.org/10.1001/archinte.1934.00160120132011
Abstract
The occurrence of pain in the joints and bones in the course of leukemia, of both the lymphatic and the myeloid type, has been recognized by clinicians for many years (Naegeli,1Poynton and his co-workers2and Smith3). These manifestations have consisted of not only pain and tenderness in the long bones, but also swelling, tenderness and redness in the joints clinically indistinguishable from that which occurs in acute rheumatic fever. These findings usually receive their correct interpretation on the basis of the existence of the hematologic and physical features of leukemia, and little diagnostic difficulty is encountered. Several cases in the aleukemic and acute states, in which the existence of leukemia was less obvious because of the absence of changes in the circulating blood and clinically demonstrable involvement of the liver, spleen and lymph nodes, have presented diagnostic problems in which, particularly, the differentiation from acute rheumaticThis publication has 0 references indexed in Scilit: