Parallel Synthesis of Oligosaccharide Conjugated Enediynes onto Silyl-linked Solid-Support
- 31 December 2001
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2001 (07) , 1101-1104
- https://doi.org/10.1055/s-2001-15164
Abstract
A solid-phase synthesis of enediyne molecules containing a sugar moiety is reported. Polymer-supported (2-mercaptoethyl)glycosides linked through a trialkylsilane linker were coupled to a bromoacetate on an enediyne by S-alkylation. After simple washing of the polymer, mild acid treatment, and evaporation, the desired oligosaccharide conjugated enediynes were isolated in pure form in parallel fashion.Keywords
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