Effects of l-tryptophan and ethanol on sleep parameters in the rat
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 58 (3) , 229-233
- https://doi.org/10.1007/bf00427384
Abstract
Sleep parameters were monitored following (1) a single 2 g/kg oral dose of ethanol, (2) an oral dose of l-tryptophan (600 mg/kg), and (3) administration of both drugs simultaneously. Ethanol reduced REM and increased slow wave significantly. The effects of l-tryptophan were apparent only in the case of one parameter, REM latency. Administration of both drugs resulted in a significantly shorter REM latency than that observed for ethanol administered alone. Results are discussed in terms of possible changes in the biosynthesis of 5-HT.Keywords
This publication has 28 references indexed in Scilit:
- Effects of the acute administration of ethanol on the sleep of the rat: A dose-response studyPharmacology Biochemistry and Behavior, 1978
- Regulation of serotonin synthesisLife Sciences, 1974
- EFFECTS OF ETHANOL ON SEROTONIN METABOLISM IN BRAINJournal of Neurochemistry, 1974
- The Cry of the Human InfantScientific American, 1974
- Tryptophan and Sleep in Young AdultsPsychophysiology, 1972
- Sleep-inducing effects of l-tryptophanJournal of Pharmacy and Pharmacology, 1972
- Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan LevelsScience, 1971
- EFFECTS OF L-TRYPTOPHAN (A NATURAL SEDATIVE) ON HUMAN SLEEPThe Lancet, 1970
- Some Experiments in the Chemistry of Normal SleepThe British Journal of Psychiatry, 1966
- Alcohol and Caffeine: Effect on Inferred Visual DreamingScience, 1963