Erythroleukemia Manifesting δβ-Thalassemia
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 7 (1) , 71-78
- https://doi.org/10.3109/03630268309038402
Abstract
A 27-yr-old male with aplastic anemia developed a high fetal Hb, a low Hb A2, a decreased .beta./.alpha. synthetic ratio and an increased G.alpha./A.gamma. synthetic ratio. This acquired hemoglobinopathy resembling .delta..beta.-thalassemia was recognized at the onset of acute erythroleukemia. Certain features of this abnormal globin synthetic pattern resemble those of the normal fetus and, thus, appear to provide another example of gene expression by malignant cells resembling that of an earlier stage of the organism''s development.This publication has 22 references indexed in Scilit:
- Erythroleukemia: A study of 15 cases and literature reviewCancer, 1982
- Long-term follow-up in patients with aplastic anemiaThe American Journal of Medicine, 1981
- Electrophoretic separation of human embryonic globin demonstrates “α-thalassemia” in human leukemia cell line K562Biochemical and Biophysical Research Communications, 1980
- Globin Chain Electrophoresis: a New Approach to the Determination of the Gγ/Aγ Ratio in Fetal Haemoglobin and to Studies of Globin SynthesisBritish Journal of Haematology, 1980
- Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic exposure to benzeneBlood, 1978
- High resolution analysis of hemoglobins: Polyacrylamide isoelectric focusingBiochemical Medicine, 1972
- Acute Erythromyelosis after Benzene PoisoningActa Haematologica, 1968
- Abnormal human haemoglobins: Separation and characterization of the α and β chains by chromatography, and the determination of two new variants, Hb chesapeake and Hb J (Bangkok)Journal of Molecular Biology, 1966
- Studies on hemoglobin F within single erythrocyte by fluorescent antibody techniqueExperimental Cell Research, 1965
- Benzene and LeukemiaNew England Journal of Medicine, 1964