The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney-medulla slices
- 15 April 1983
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 212 (1) , 167-171
- https://doi.org/10.1042/bj2120167
Abstract
Lipid peroxidation induced by ascorbic acid and Fe2+ was inhibited by mepacrine (phospholipase A2 inhibitor) and aspirin (prostaglandin cyclo-oxygenase inhibitor) in rabbit kidney-medulla slices. Moreover, ascorbic acid and Fe2+ potentiated the inhibitory effect on prostaglandin E2 formation by mepacrine, but they had no influence on prostaglandin E2 production decreased by aspirin. Lipid peroxidation induced by ascorbic acid and Fe2+ appears to be affecting the activity of prostaglandin endoperoxide synthase. These results suggest that lipid peroxidation is connected closely with the prostaglandin-generating system, and it has the potential to modulate the turnover of arachidonic acid and prostaglandin synthesis.This publication has 21 references indexed in Scilit:
- Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.Journal of Biological Chemistry, 1976
- The importance of phospholipase-A2 in prostaglandin biosynthesisBiochemical Pharmacology, 1976
- Analyses of renal medullary lipid droplets from normal, hydronephrotic, and indomethacin treated rabbitsLipids, 1975
- Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursorsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975
- Quantitative and qualitative analyses of isolated lipid droplets from interstitial cells in renal papillae from various speciesLipids, 1974
- Prostaglandin Synthetase System—Resolution into Oxygenase and Isomerase ComponentsProceedings of the National Academy of Sciences, 1974
- Lipid peroxidation damage to cell components.1973
- Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like DrugsNature New Biology, 1971
- A sensitive method for the determination of prostaglandins by gas chromatography with electron-capture detectionBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970
- Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehydeBiochemistry, 1969