Efficacy of topotecan treatment on antioxidant enzymes and TBA‐RS levels in submandibular glands of rabbits: An experimental study

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Abstract
OBJECTIVE: The aim of this study was to investigate the effects of topotecan (Hycamtin), a topoisomerase I inhibiting anticancer agent, on antioxidant enzymes (SOD, CAT, and GSH‐Px) and TBA‐RS values of the submandibular glands of the rabbits.STUDY DESIGN AND SETTING: The study was conveyed in two groups (Group I, II) and control with a total of 24 rabbits. Eight rabbits in group I received intravenous (i.v.) topotecan (0.25 mg/kg once daily) for 3 days. Eight rabbits in group II received i.v. topotecan (0.5 mg/kg once daily) for 3 days. On the 15th day after administration of topotecan, sub‐mandibular glands were removed and levels of the SOD, CAT, and GSH‐Px and the TBA‐RS in the sub‐mandibular glands of the rabbits were examined.RESULTS: SOD, CAT, and GSH‐Px values were significantly higher in high‐dose topotecan group compared to control group (P < 0.05). SOD and TBA‐RS values were significantly higher in high‐dose topotecan group compared to low‐dose topotecan group (P < 0.05).CONCLUSION: It was concluded that, to prevent the hazardous effects of oxygen free radicals due to topotecan, antioxidant enzymes SOD, CAT, and GSH‐Px were increased. The higher levels of the TBA‐RS values in group II showed that permanent damage was present because of high‐dose topotecan administration in the submandibular glands of the rabbits.