The Elimination of Chromosome Aberrations in Liver Cells by Cell Division

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Abstract
Chromosome aberrations have been scored in regenerating liver cells in mice after a large single dose of X-rays and with and without repeated doses of CCl4 which stimulate cell division in the liver. The purpose of the experiment was to assess the role of cell division in the elimination of chromosome aberrations. It is concluded that it may take 4 or more cell divisions before an aberration produced by X-ray is eliminated from liver cells. This is not rapid enough to account for the elimination of chromosome aberrations induced in liver by X-irradiation. It is concluded that there is healing of broken chromosomes in interphase nuclei; small breaks or latent breaks can be healed quickly, severe breaks can heal over a period of months without cell division, and very severe breaks such as those caused by neutrons are apparently never healed.