Io: A Surface Evaporite Deposit?
- 6 December 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4167) , 922-925
- https://doi.org/10.1126/science.186.4167.922
Abstract
In subconfluent cultures of fibroblasts from patients with complete or partial deficiencies of hypoxanthine-guanine phosphoribosyltransferase, phosphoribosylpyrophosphate synthetase activity is elevated. The abnormally high catalytic activity of the synthetase appears to account for the overproduction of purines by the cultured mutant cells and presumably for that by the patients.Keywords
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