EFFECTS OF IN VIVO ESTRADIOL ADMINISTRATION ON AVAILABILITY OF RAT UTERINE NUCLEAR ACCEPTOR SITES MEASURED IN VITRO

1 August 1984

journal article
Published by The Endocrine Society in Endocrinology

Vol. 115 (2) , 836-838
https://doi.org/10.1210/endo-115-2-836

Abstract

Estradiol injected in vivo successfully completes for binding to uterine nuclear acceptor sites measured by the assay of Kon and Spelsberg (1). Such competition is time-and dose-dependent, with maximal inhibition (75%) 1 h after injection and at a dose of 10 micrograms of 17 beta-estradiol per 300 g of BW. Thus, this assay appears to accurately measure those uterine nuclear acceptor sites mediating estrogen action in vivo.

Keywords

ESTROGEN
UTERINE NUCLEAR
NUCLEAR ACCEPTOR
ACCEPTOR SITES
VIVO ESTRADIOL
ESTRADIOL ADMINISTRATION
SITES MEASURED

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