Mutarotase activity in serum and urine of patients with renal disease.

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Abstract
Mutarotase activity in the serum and urine of normal subjects and patients with known renal disease was determined with our mutarotase assay using an oxygen electrode and β-D-glucose oxidase. The activities of alkaline phosphatase and lactate dehydrogenase in serum and urine were also determined. Mutarotase activity was found to be present in the human urine. Elevated urinary mutarotase levels were observed in 7 of the 8 patients with nephrotic syndrome. Urinary levels of two other enzymes were also raised in the same case. Any marked elevation of serum mutarotase, alkaline phosphatase, and lactate dehydrogenase levels was not observed. Urinary mutarotase activity was related to the clinical state of patients with nephrotic syndrome.
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