Special report: dysoxia. Abnormal tissue oxygen utilization

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Abstract
The ultimate cause of the [human] clinical abnormalities associated with changes in oxygen supply and oxygen utilization is the development of abnormal tissue oxygen metabolism. This abnormality can be described as dysoxia. There are a number of causes of dysoxia. One form of dysoxia is related to abnormal mitochondrial structure and function. In this group of disorders, there is abnormal tissue oxygen metabolism, although oxygen supply is normal. Another cause of dysoxia is exposure to high oxygen concentrations. High oxygen concentrations produce abnormal tissue oxygen metabolism under a number of different circumstances. The concept underlying dysoxia provides a unified approach to a large group of disorders involving most of clinical medicine.