T Lymphocyte Recognition of Alloantigen in Vitro

Publisher Website
Google Scholar
Abstract
The present experiments were curried out in order to answer the question whether the precursor T cells of cytotoxic T lymphocytes (PCTL) are Fc receptor positive (FcR+). Fc receptor negative (FcR−), or both. The data show that cytotoxic T lymphocytes (CTL) can be generated in vitro from both FcR+ and FcR− PCTL. Furthermore, we investigated if the function of FcR+ and FcR− CTL differed in the allograft response in vitro. Qualitatively, FcR− PCTL differentiate into FcR− CTL only, whereas FcR+ PCTL differentiate into both FcR+ and FcR− CTL. However, quantitatively, CTL generated from FcR+ PCTL display a higher T cell mediated cytotoxicity than CTL generated from FcR+ PCTL. Mixing experiments indicate that FcR+ T cells regulate the differentiation of FcR− PCTL into CTL. These conclusions hold true for PCTL in both normal and memory responder cell populations.