Reactions of 4-Hydroxy-6-Methyl-2-Pyridone with aldehydes And Glyoxals

Abstract
Recently we reported the structure 1 for flavipucine, an antibiotic factor isolated from culture filtrates of Aspergillus flavipes.1 In considering synthetic approaches to this novel highly functionalized system we regarded compounds 2a and 2b to be potentially useful intermediates. This prompted us to study the reactions of 4-hydroxy-6-methyl-2-pyridone2 with some aldehydes and glyoxals.

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