Muscle Damage and Recovery in the Rabbit Tongue Following Photodynamic Therapy with Haematoporphyrin Derivative
- 1 January 1991
- journal article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 111 (1) , 153-160
- https://doi.org/10.3109/00016489109137367
Abstract
To study the effects of photodynamic therapy on the tissues of the tongue, 20 New Zealand White rabbits were injected intravenously with haematoporphyrin derivative. Their tongues and those of 2 controls were illuminated with 100 J/cm2 of red light from a copper vapour-pumped dye laser emitting light at 625 nm. The rabbits were sacrificed at intervals between 2 days and 12 weeks following treatment. Their tongues were examined histologically. Initially there was marked damage to mucosa, muscle and blood vessels. However, this healed by a mixture of regeneration and scarring.Keywords
This publication has 8 references indexed in Scilit:
- Meso-Tetra(hydroxyphenyl)porphyrins, a new class of potent tumour photosensitisers with favourable selectivityBritish Journal of Cancer, 1986
- Cerebral photosensitisation by haematoporphyrin derivative. Evidence for an endothelial site of actionBritish Journal of Cancer, 1986
- Photodynamic Therapy in Head and Neck CancerJAMA Otolaryngology–Head & Neck Surgery, 1985
- The Biology of Head and Neck Cancer: Detection and Control by Parallel Histologic SectionsJAMA Otolaryngology–Head & Neck Surgery, 1984
- Laser photoradiation therapy of cancer: An update of the experience at the university of California, IrvineLasers in Surgery and Medicine, 1984
- On the nature of ‘haematoporphyrin derivative’Journal of the Chemical Society, Perkin Transactions 1, 1981
- Carcinoma of the tongue: Factors affecting the results of surgical treatmentBritish Journal of Surgery, 1980
- Cancer of the tongue. Report of the management of 1,554 patientsCancer, 1962