SEVERE COMBINED IMMUNODEFICIENCY WITH THYMIC MAST-CELL HYPERPLASIA

  • 1 January 1976
    • journal article
    • research article
    • Vol. 100  (5) , 283-286
Abstract
The autopsy finding on an infant with severe combined immunodeficiency was marked thymic mast cell hyperplasia. The clinical immune status showed a deficit in T (thymus derived) lymphocytes and low immunoglobulin levels. The autopsy showed the histologic pattern designated thymic alymphoplasia and a marked lack of development of the RES organs. The mast cell hyperplasia may be the result of an antigenic stimulus early in embryonic life and/or the result of mast cell differentiation at the expense of normal thymic lymphoid development caused by a genetic defect.

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