CSF neuron‐specific enolase after methohexital activation during electrocorticography
- 1 June 1994
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 44 (6) , 1167
- https://doi.org/10.1212/wnl.44.6.1167
Abstract
We report changes in CSF and serum neuron-specific enolase (NSE) before and after methohexital infusion during electrocorticography in three patients undergoing epilepsy surgery. NSE is a critical enzyme for energy metabolism that accounts for 1.5% of all soluble brain protein and is an accepted marker of neuronal injury. CSF NSE rose three to fourfold from baseline within 60 minutes after methohexital activation. Serum NSE was unchanged. This report supports evidence that CSF NSE rises acutely after induction of epileptiform activity and suggests that CSF NSE is a marker of seizure activity.This publication has 7 references indexed in Scilit:
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