The effect of mepyramine and ranitidine on the oestrogen and anti‐oestrogen stimulated rat uterus

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Abstract
1 The aims of this study were to elucidate further the role of histamine in the rat uterotrophic response and to investigate the differences between the oestrogen and the anti-oestrogen induced uterine responses. 2 The parameters examined were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights. 3 17β-Oestradiol and the anti-oestrogen, tamoxifen, were used to stimulate the ovariectomised rat uterus and the antihistamines mepyramine (H1) and ranitidine (H2) were employed to modify these responses. 4 The uterine changes evoked by oestradiol proved to be more susceptible to modification by the antihistamines than the tamoxifen-stimulated responses. 5 The results suggest that histamine is involved in the early uterine response to oestradiol but histamine does not appear to play a major role in the uterine response to tamoxifen.