DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation
Top Cited Papers
Open Access
- 25 August 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 34 (15) , 4206-4215
- https://doi.org/10.1093/nar/gkl460
Abstract
The DExD/H box family of proteins includes a large number of proteins that play important roles in RNA metabolism. Members of this family have been shown to act as RNA helicases or unwindases, using the energy from ATP hydrolysis to unwind RNA structures or dissociate RNA-protein complexes in cellular processes that require modulation of RNA structures. However, it is clear that several members of this family are multifunctional and, in addition to acting as RNA helicases in processes such as pre-mRNA processing, play important roles in transcriptional regulation. In this review I shall concentrate on RNA helicase A (Dhx9), DP103 (Ddx20), p68 (Ddx5) and p72 (Ddx17), proteins for which there is a strong body of evidence showing that they play important roles in transcription, often as coactivators or corepressors through their interaction with key components of the transcriptional machinery, such as CREB-binding protein, p300, RNA polymerase II and histone deacetylases.Keywords
This publication has 105 references indexed in Scilit:
- Dead-box proteins: a family affair—active and passive players in RNP-remodelingNucleic Acids Research, 2006
- Good cop, bad cop: the different faces of NF-κBCell Death & Differentiation, 2006
- Helicases: amino acid sequence comparisons and structure-function relationshipsPublished by Elsevier ,2005
- The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressorThe EMBO Journal, 2005
- Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target PromoterCell, 2003
- Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300Oncogene, 2003
- Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumoursOncogene, 2001
- A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor α coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRAThe EMBO Journal, 2001
- RNA helicase activity associated with the human p68 proteinNature, 1989
- Nuclear protein with sequence homology to translation initiation factor eIF-4ANature, 1988