Combination of LC−MS and LC−NMR as a Tool for the Structure Determination of Natural Products
- 1 February 1998
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (2) , 175-178
- https://doi.org/10.1021/np970416z
Abstract
Application of both LC−MS and LC−NMR to a partially purified extract of Vernonia fastigiata led to the direct identification of antibacterial sesquiterpene lactones 1−9 without isolation of individual compounds. The rapid structural analysis of both major and minor components of this class of compounds demonstrated the power of structure-guided screening as a complementary method to assay-guided screening.Keywords
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