Different Secretory IgA Antibody Responses After Immunization with Inactivated and Live Poliovirus Vaccines
- 1 May 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 6 (Supplement) , S356-S360
- https://doi.org/10.1093/clinids/6.supplement_2.s356
Abstract
The influence on secretory IgA antibody levels in milk and saliva of vaccination with oral, live poliovirus vaccine (OPV) and inactivated poliovirus vaccine (IPV) was studied. IPV, especially the antigen-rich Dutch vaccine, more often induced increases in antibody titers in milk (50%) than did OPV (26%) (P < .01). OPV more often decreased the antibody levels in milk (40%) than did IPV (10%) ( P < .01). It was striking that mainly high prevaccination titers were decreased. The increases of IgA antibody in saliva were less striking. IPV caused increases as often in milk as in saliva, whereas OPV more often induced increases in IgA antibody in saliva, but there was a poor correlation between the changes in antibody titers in milk and those in saliva.Keywords
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