Hepatic Lipogenesis in Acute Uremic Syndrome

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Abstract
To define more clearly the role of hepatic lipogenesis in the uremic hypertriglyceridemia, in vitro studies with rat liver slices have been conducted. Liver slices from fasted rats which had been nephrectomized 24 h before sacrifice, showed a significant increase in the incorporation of acetate-2–14C into triglycerides, when compared to both sham-operated and unoperated controls. The conversion of the label to cholesterol was substantially higher in the nephrectomized as well as in the sham-operated rats than in the unoperated controls. No significant difference was observed in the radioactivity of phospholipids or CO2between the 3 groups. The data are compatible with specific stimulating action of acute uremic syndrome upon hepatic triglyceride synthesis. On the other hand, the striking enhancement in hepatic cholesterogenesis was induced by the surgical stress as such.

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