THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY
Open Access
- 1 October 1927
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 46 (4) , 609-614
- https://doi.org/10.1084/jem.46.4.609
Abstract
1. The minimum amount of diphtheria toxin which killed normal mice of from 24 to 30 gm. in weight upon intravenous injection, was found to be between 75 and 100 times the M.F.D. for the guinea pig. When given intraperitoneally, the fatal dose for mice was as high as 200 M.F.D. 2. There was no significant difference in the lethal action of diphtheria toxin for normal mice and mice in which an elimination of the reticulo-endothelial system had been attempted by means of blocking injections of India ink, or splenectomy, or a combination of both operations. 3. Attempts to infect normal mice and mice treated as described with large doses of a highly virulent diphtheria strain were unsuccessful with both groups of animals.This publication has 2 references indexed in Scilit:
- EXPERIMENTS ON THE RÔLE OF LYMPHOID TISSUE IN THE RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN MICEThe Journal of Experimental Medicine, 1914
- THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSISThe Journal of Experimental Medicine, 1914