In vitro and in vivo antibacterial activities of florfenicol, a new fluorinated analog of thiamphenicol, against fish pathogens.

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Abstract
The present study determined the in vitro and in vivo antibacterial activities of florfenicol (FF) against the various fish pathogens; Pasteurella piscicida, Vibrio anguillarum, Edwardsiella tarda, Aeromonas hydrophila and A. salmonicida. FF demonstrated highly potent antibacterial activity against various fish pathogens inhibiting the growth of all of the test strains resistant to thiamphenicol (TP), chloramphenicol (CP) and other antimicrobials at the same MICs as drug-susceptible strains. In experimentally induced infections of P. piscicida in yellowtail, E. tarda in eel and V. anguillarum in goldfish, FF proved to be very effective by the oral route and its efficacy was superior to that of TP, CP and oxytetracycline.

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