Effect of Human Immunoglobulin Preparations on ExperimentalBordetella pertussisInfection in Mice

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Abstract
Abstracts.The effects of four kinds of human immunoglobulin preparations for intravenous use [pH‐4‐treated (IG‐100), polyethyleneglycol‐treated (PEG‐G), sulfonated (S‐G) and pepsin‐treated (Pep‐G)] on intracerebral (i.c.)Bordetella pertussisinfection in mice, and onB. pertussisvaccine‐induced leukocytosis‐promoting factor (LPF) and histamine‐sensitizing factor (HSF) were compared with those of human immunoglobulin preparation for intramuscular use (GGN). A prophylactic potential against i.c.B. pertussischallenge was demonstrated in IG‐100, PEG‐G and GGN. A prophylactic potential was also demonstrated in S‐G and Pep‐G, although to a lesser extent. Neutralizing activity for LPF was in the following order: GGN = IG‐100 = PEG‐G > S‐G = Pep‐G; for HSF it was as follows: IG‐100 > PEG‐G > GGN = S‐G > Pep‐G. There were no significant differences in antibody titers of the various preparations againstB. pertussisantigens. These results suggest that the Fc part of the immunoglobulin molecule is important for protecting against i.c.B. pertussisinfection and for neutralizingB. pertussistoxins.