Induction of B Cell Unresponsiveness to Noninherited Maternal HLA Antigens During Fetal Life
- 30 September 1988
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 241 (4874) , 1815-1817
- https://doi.org/10.1126/science.3051377
Abstract
Patients who have received many transfusions become highly sensitized and develop antibodies against almost all HLA alloantigens, so that finding a cross-match negative kidney donor is difficult. A survey of those patients showed that 50 percent did not form antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical implications, the data indicate that a human equivalent of murine neonatal or actively acquired tolerance has now been identified.Keywords
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