Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity
- 31 October 2004
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 36 (12) , 1255-1257
- https://doi.org/10.1038/ng1469
Abstract
Splice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found five significant biases indicating that their distribution is nonrandom and that they are evolutionarily conserved and tissue-specific. Because of their subtle effects on mRNA and protein structures, these splice acceptors are often overlooked or underestimated, but they may have a great impact on biology and disease.Keywords
This publication has 12 references indexed in Scilit:
- Alternative splicing in disease and therapyNature Biotechnology, 2004
- Stochastic yet biased expression of multiple Dscam splice variants by individual cellsNature Genetics, 2004
- Assessing the Impact of Alternative Splicing on Domain Interactions in the Human ProteomeJournal of Proteome Research, 2003
- Protein–protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfacesProceedings of the National Academy of Sciences, 2003
- Alternative splicing of prosystemin pre-mRNA produces two isoforms that are active as signals in the wound response pathwayPlant Molecular Biology, 2001
- An Alternative-Exon Database and Its Statistical AnalysisDNA and Cell Biology, 2000
- Evidence for a linear search in bimolecular 3′ splice site AG selectionProceedings of the National Academy of Sciences, 2000
- Association of intron phases with conservation at splice site sequences and evolution of spliceosomal intronsMolecular Biology and Evolution, 1999
- Alternative Nonallelic Deletion Is Constitutive of Ruminant αs1-CaseinProtein Journal, 1999
- Effect of genotype on the levels of surfactant protein A mRNA and on the SP-A2 splice variants in adult humansBiochemical Journal, 1997